This week's Diabetes Bulletin...

...

Friday 29 August 2008

BMJ Learning Modules

The following diabetes modules are available using your NHS Athens password, to see more diabetes related modules go to http://www.bmjlearning.com/:

Diabetes mellitus type 2: an update on management
Many advances have been made in the treatment of type 2 diabetes. Would you like an update on postprandial glucose regulators, DPP-4 inhibitors, insulin glargine and detemir? This recently updated module will tell you all about these important drugs. Click on the link to complete it today.

Hypoglycaemia: diagnosis and management
Hypoglycaemia is one of the most unpleasant and feared acute complications of diabetes. The symptoms and signs can be overlooked in the early stages. Prompt effective treatment should be readily available. Complete this module to improve the diagnosis and management of people who experience episodes of hypoglycaemia

Recent Big 4 diabetes articles

[Department of Error] Department of Error
...type 2 diabetes on oral hypoglycaemic agents (APOLLO): an open randomised controlled trial. Lancet 2008; 371: 1073–84—In this Article (March 29), the fifth line from the bottom of the panel (p 1075) should have read: “≤5·5 mmol/L: no further titration”. The second sentence of the footnote to table 2 (p 1079) should have read: “Fasting blood gluc...
The Lancet - 10:40 (1 hour ago)


[Correspondence] Intensive insulin therapy in patients with type 2 diabetes – Authors' reply
...latent autoimmune diabetes in adults in our population. Although there is no formal consensus regarding diagnostic criteria, the disorder is generally defined as GAD antibody positivity in adult diabetic patients who do not initially (for at least 6 months) require insulin. Usually patients with latent autoimmune diabetes have a low body-mass in...
The Lancet - 10:40 (1 hour ago)


[Correspondence] Intensive insulin therapy in patients with type 2 diabetes
...type 2 diabetes (May 24, p 1573) is an exciting prospect.
The Lancet - 10:40 (1 hour ago)


[Correspondence] Intensive insulin therapy in patients with type 2 diabetes
Jianping Weng and colleagues are to be commended for building a concept that could change clinical practice. However, their conclusions need some clarification.
The Lancet - 10:40 (1 hour ago)


CORRESPONDENCE: Widespread Amyloid Deposition in Transplanted Human Pancreatic Islets
...type 1 diabetes mellitus, diagnosed at 16 years of age, in ...
New England Journal of Medicine - 27 Aug 2008 (2 days ago)



CARING FOR THE CRITICALLY ILL PATIENT: Benefits and Risks of Tight Glucose Control in Critically Ill Adults: A Meta-analysis
...The American Diabetes Association and Surviving Sepsis Campaign recommend tight glucose control in critically ill patients based largely on 1 trial that shows decreased mortality in a surgical intensive care unit. Because similar studies report conflicting results and tight glucose control can cause dangerous hypoglycemia, the data underlying th...
JAMA current issue - 26 Aug 2008 (3 days ago)


[RESEARCH] Role of blood pressure in development of early retinopathy in adolescents with type 1 diabetes: prospective cohort study
...type 1 diabetes. Design Prospective cohort study. Setting Diabetes Complications Assessment Service at the Children’s Hospital at Westmead, Sydney, Australia. Participants 1869 patients with type 1 diabetes (54% female) screened for retinopathy with baseline median age 13.4 (interquartile range 12.0-15.2) years, duration 4.9 (3.1-7.0) years, and...
BMJ current issue - 26 Aug 2008 (3 days ago)


[EDITORIALS] Complications of type 1 diabetes in adolescents
BMJ current issue - 26 Aug 2008 (3 days ago)


[NEWS] Diabetes care needs to focus more on ethnic inequalities, say experts
BMJ current issue - 22 Aug 2008 16:46

[PRACTICE] Should we prescribe diuretics for patients with prediabetes and hypertension?
BMJ current issue - 21 Aug 2008 14:44


LETTERS: Insulin Therapy and Lipid Overload in Type 2 Diabetes--Reply
JAMA current issue - 19 Aug 2008 21:44

LETTERS: Insulin Therapy and Lipid Overload in Type 2 Diabetes
JAMA current issue - 19 Aug 2008 21:44

LETTERS: Pioglitazone vs Glimepiride in the PERISCOPE Trial
JAMA current issue - 19 Aug 2008 21:44


EDITORIAL: Environmental Arsenic Exposure and Diabetes
JAMA current issue - 19 Aug 2008 21:44

LETTERS: Pioglitazone vs Glimepiride in the PERISCOPE Trial--Reply
JAMA current issue - 19 Aug 2008 21:44



LETTERS: Pioglitazone vs Glimepiride in the PERISCOPE Trial
JAMA current issue - 19 Aug 2008 21:44


LETTERS: Insulin Therapy and Lipid Overload in Type 2 Diabetes
JAMA current issue - 19 Aug 2008 21:44


PRELIMINARY COMMUNICATION: Arsenic Exposure and Prevalence of Type 2 Diabetes in US Adults
...related to diabetes development, but the effect of exposure to low to moderate levels of inorganic arsenic on diabetes risk is unknown. In contrast, arsenobetaine, an organic arsenic compound derived from seafood intake, is considered nontoxic. Objective To investigate the association of arsenic exposure, as measured in urine, with the prevalen...
JAMA current issue - 19 Aug 2008 21:44

[Seminar] Acute myocardial infarction
...epidemic of diabetes and obesity in the developed world and the transition from infectious diseases to cardiovascular disease in the developing world will place an increasing demand on health-care infrastructures required to deliver time-dependent and resource-intensive care. This Seminar discusses the underlying pathophysiology, evolving perspe...
The Lancet - 15 Aug 2008 11:00

[Articles] Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial
...or with diabetes with end-organ damage.
The Lancet - 15 Aug 2008 11:00

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 25-2008 -- A 43-Year-Old Man with Fatigue and Lesions in the Pituitary and Cerebellum
...Diabetes insipidus, hypogonadism, and hypothyroidism had developed beginning 9 years earlier, and lesions had been detected in the region of the pituitary stalk and in the cerebellum. He was treated with glucocorticoids for suspected neurosarcoidosis, but fatigue, ataxia, and neurologic symptoms worsened. Computed tomography of the chest and abd...
New England Journal of Medicine - 13 Aug 2008 22:25

[CORRECTIONS] Evidence shows higher long term risks from gestational diabetes
BMJ current issue - 6 Aug 2008 17:36

Basal insulin glargine vs prandial insulin lispro in type 2 diabetes
Reinhard Bretzel and colleagues (March 29, p 1073) compared once-daily insulin glargine with thrice-daily prandial insulin lispro as add-on therapy to continued oral hypoglycaemic agents. Although glycosylated haemoglobin did not differ between regimens, the overall incidence of hypoglycaemic events was four times higher with insulin lispro than wi...
The Lancet - 1 Aug 2008 11:15

Basal insulin glargine vs prandial insulin lispro in type 2 diabetes – Authors' reply
Sabine Arnolds and Klaus Rave state that the higher hypoglycaemic rate in the lispro group than in the glargine group was potentiated by the presence of glimepiride. However, the relative frequencies of hypoglycaemic events by hour of day showed a similar distribution profile, with peaks at 2 pm for lispro and 3 pm for glargine. A further explanati...
The Lancet - 1 Aug 2008 11:15

Department of Health (DH) Publication

Five years on: delivering the diabetes national service framework http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_087123

NICE guidance updates

The following guidance matching your health area preferences has been published or updated:

Diabetes (type 2) - newer agents
Diabetes - insulin pump therapy
Diabetes - type 2 (update)
Type 1 diabetes
Diabetes - type 2 (update)

Diabetes Care Vol 31; Part 8; August 2008

We have full text access to these articles. Click here to access the journal. You will need an NHS Athens password to access the full text of articles.


Evaluation of a System for Automatic Detection of Diabetic Retinopathy From Color Fundus Photographs in a Large Population of Patients With Diabetes : Response to Abrà ; moff et al .
Author(s):John A . Olson
Page:
e63 - e63

Evaluation of a System for Automatic Detection of Diabetic Retinopathy From Color Fundus Photographs in a Large Population of Patients With Diabetes : Response to Olson et al .
Author(s):Michael D . Abrà ; moff
Page:
e64 - e64

Translating the A1C Assay Into Estimated Average Glucose Values
Author(s):David M . Nathan
Page:
1473 - 1478

Colesevelam HCl Improves Glycemic Control and Reduces LDL Cholesterol in Patients With Inadequately Controlled Type 2 Diabetes on Sulfonylurea - Based Therapy
Author(s):Vivian A . Fonseca
Page:
1479 - 1484

Influence of and Optimal Insulin Therapy for a Low - Glycemic Index Meal in Children With Type 1 Diabetes Receiving Intensive Insulin Therapy
Author(s):Rochelle L . Ryan
Page:
1485 - 1490

Optimizing Postprandial Glycemia in Pediatric Patients With Type 1 Diabetes Using Insulin Pump Therapy : Impact of glycemic index and prandial bolus type
Author(s):Michele A . O'Connell
Page:
1491 - 1495

Clinical Application of 1 , 5 - Anhydroglucitol Measurements in Patients with Hepatocyte Nuclear Factor - 1&agr ; Maturity - Onset Diabetes of the Young
Author(s):Jan Skupien
Page:
1496 - 1501

Hemodynamic Effects of Fenofibrate and Coenzyme Q10 in Type 2 Diabetic Subjects With Left Ventricular Diastolic Dysfunction
Author(s):Gerard T . Chew
Page:
1502 - 1509

Cost - Effectiveness of Intensified Versus Conventional Multifactorial Intervention in Type 2 Diabetes : Results and projections from the Steno - 2 study
Author(s):Peter Gæ ; de
Page:
1510 - 1515

Diabetes Complications in Youth : Qualitative analysis of parents` perspectives of family learning and knowledge
Author(s):
Lisa M . Buckloh
Page:
1516 - 1520

Monitoring and Discussing Health - Related Quality of Life in Adolescents With Type 1 Diabetes Improve Psychosocial Well - Being : A randomized controlled trial
Author(s):Maartje de Wit
Page:
1521 - 1526

Blood Glucose Awareness Training Delivered Over the Internet
Author(s):Daniel Cox
Page:
1527 - 1528

Evaluation of a Systems Navigator Model for Transition From Pediatric to Adult Care for Young Adults With Type 1 Diabetes
Author(s):Norma Van Walleghem
Page:
1529 - 1530

Impaired Chronotropic Response to Exercise Stress Testing in Patients With Diabetes Predicts Future Cardiovascular Events
Author(s):P . Michael Ho
Page:
1531 - 1533

Association of 1 , 5 - Anhydroglucitol and 2 - h Postprandial Blood Glucose in Type 2 Diabetic Patients
Author(s):
Christoph Stettler
Page:
1534 - 1535

Risks of Nontraumatic Lower - Extremity Amputations in Patients with Type 1 Diabetes : A population - based cohort study in Sweden
Author(s):
Junmei Miao Jonasson
Page:
1536 - 1540

Diabetes , Glycemic Control , and Risk of Hospitalization With Pneumonia : A population - based case - control study
Author(s):
Jette B . Kornum
Page:
1541 - 1545

The Rising Incidence of Type 1 Diabetes Is Accounted for by Cases With Lower - Risk Human Leukocyte Antigen Genotypes
Author(s):
Spiros Fourlanos
Page:
1546 - 1549

Insulin Sensitivity Measured With Euglycemic Clamp Is Independently Associated With Glomerular Filtration Rate in a Community - Based Cohort
Author(s):
Elisabet Nerpin
Page:
1550 - 1555

Economic Benefits of Intensive Insulin Therapy in Critically Ill Patients : The Targeted Insulin Therapy to Improve Hospital Outcomes ( TRIUMPH ) Project
Author(s):
Archana R . Sadhu
Page:
1556 - 1561

Health Care Use and Costs Associated With Use of a Health Club Membership Benefit in Older Adults with Diabetes
Author(s):
Huong Q . Nguyen
Page:
1562 - 1567

Dietary Patterns and A1C in Japanese Men and Women
Author(s):
Akiko Nanri
Page:
1568 - 1573

Increased Risk of Diabetes and Polychlorinated Biphenyls and Dioxins : A 24 - year follow - up study of the Yucheng cohort
Author(s):
Shu - Li Wang
Page:
1574 - 1579

Sexual Dysfunction in Jordanian Diabetic Women
Author(s):
Ruba M . Abu Ali
Page:
1580 - 1581

Lifetime Risk of Cardiovascular Disease Among Individuals With and Without Diabetes Stratified by Obesity Status in the Framingham Heart Study
Author(s):
Caroline S . Fox
Page:
1582 - 1584

Association Between p . Leu54Met Polymorphism at the Paraoxonase - 1 Gene and Plantar Fascia Thickness in Young Subjects With Type 1 Diabetes
Author(s):
Patricia H . Gallego
Page:
1585 - 1589

Hyperglycemia Is Associated With Enhanced Thrombin Formation , Platelet Activation , and Fibrin Clot Resistance to Lysis in Patients With Acute Coronary Syndrome
Author(s):
Anetta Undas
Page:
1590 - 1595

Diminished Alveolar Microvascular Reserves in Type 2 Diabetes Reflect Systemic Microangiopathy
Author(s):
William W . Chance
Page:
1596 - 1601

GAD65 Autoantibody Responses in Japanese Latent Autoimmune Diabetes in Adult Patients
Author(s):
Taro Maruyama
Page:
1602 - 1607

Differences in the Contribution of the CTLA4 Gene to Susceptibility to Fulminant and Type 1A Diabetes in Japanese Patients
Author(s):
Eiji Kawasaki
Page:
1608 - 1610

Epidermal Innervation in Type 1 Diabetic Patients : A 2 . 5 - year prospective study after simultaneous pancreas / kidney transplantation
Author(s):
Petr Boucek
Page:
1611 - 1612

Short - Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function
Author(s):
Sebastiaan Hammer
Page:
1613 - 1614

Serum Bilirubin and Ferritin Levels Link Heme Oxygenase - 1 Gene Promoter Polymorphism and Susceptibility to Coronary Artery Disease in Diabetic Patients
Author(s):
Ying - Hwa Chen
Page:
1615 - 1620

Association of Acculturation Levels and Prevalence of Diabetes in the Multi - Ethnic Study of Atherosclerosis ( MESA )
Author(s):
Namratha R . Kandula
Page:
1621 - 1628

Preventing Left Ventricular Hypertrophy by ACE Inhibition in Hypertensive Patients With Type 2 Diabetes : A prespecified analysis of the Bergamo Nephrologic Diabetes Complications Trial ( BENEDICT )
Author(s):
Piero Ruggenenti
Page:
1629 - 1634

Dysglycemia and a History of Reproductive Risk Factors
Author(s):
Sarah D . McDonald
Page:
1635 - 1638

Risk of Glucose Intolerance and Diabetes in Hemipancreatectomized Donors Selected for Normal Preoperative Glucose Metabolism
Author(s):
Anjali F . Kumar
Page:
1639 - 1643

Increased Daily Walking Improves Lipid Oxidation Without Changes in Mitochondrial Function in Type 2 Diabetes
Author(s):
Michael I . Trenell
Page:
1644 - 1649

One - Hour Plasma Glucose Concentration and the Metabolic Syndrome Identify Subjects at High Risk for Future Type 2 Diabetes
Author(s):
Muhammad A . Abdul - Ghani
Page:
1650 - 1655

Dose - Dependent Effect of Rosuvastatin on VLDL - Apolipoprotein C - III Kinetics in the Metabolic Syndrome
Author(s):
Esther M . M . Ooi
Page:
1656 - 1661

Sex - Specific Association of the Putative Fructose Transporter SLC2A9 Variants With Uric Acid Levels Is Modified by BMI
Author(s):
Anita Br and stä ; tter
Page:
1662 - 1667

Increased Risk of Cardiovascular Disease in Young Women Following Gestational Diabetes Mellitus
Author(s):
Baiju R . Shah
Page:
1668 - 1669

Validation of Prediction of Diabetes by the Archimedes Model and Comparison With Other Predicting Models
Author(s):
Michael Stern
Page:
1670 - 1671

Is the Combination of Sulfonylureas and Metformin Associated With an Increased Risk of Cardiovascular Disease or All - Cause Mortality ? : A meta - analysis of observational studies
Author(s):
Ajay D . Rao
Page:
1672 - 1678

Comprehensive Foot Examination and Risk Assessment : A report of the Task Force of the Foot Care Interest Group of the American Diabetes Association , with endorsement by the American Association of Clinical Endocrinologists
Author(s):
Andrew J . M . Boulton
Page:
1679 - 1685

The Impact of Prevention on Reducing the Burden of Cardiovascular Disease
Author(s):
Richard Kahn
Page:
1686 - 1696

Approaches to Treatment of Type 2 Diabetes
Author(s):
Zachary T . Bloomgarden
Page:
1697 - 1703

Translating the A1C Assay
Author(s):
Richard Kahn
Page:
1704 - 1707

Reducing Cardiovascular Disease : Opportunities and consequences
Author(s):
Peter J . Neumann
Page:
1708 - 1709