Latest Diabetes articles in the Big 4

BOOK REVIEW: Controversies in Treating Diabetes: Clinical and Research Aspects
Shortly before his election as president, John F. Kennedy wrote, "Let us welcome controversial books and controversial authors." To this statement we might add "and books on controversial medical topics," ...
New England Journal of Medicine - Jul 16, 2008 (2 days ago)

ORIGINAL CONTRIBUTION: Fetuin-A and Incident Diabetes Mellitus in Older Persons
...type 2 diabetes mellitus is unknown. Objective To determine whether fetuin-A levels are associated with incident diabetes in older persons. Design, Setting, and Participants Observational study among 3075 well-functioning persons aged 70 to 79 years. In this case-cohort study, we retrospectively measured fetuin-A levels in baseline serum among...
JAMA current issue - Jul 8, 2008 9:39 PM

β-cell transplantation for diabetes therapy
In their Comment, Piero Ruggenenti and colleagues outline why they have decided not to continue islet-cell transplantation. We wish to clarify several points for readers.
The Lancet - Jul 4, 2008 10:48 AM

β-cell transplantation for diabetes therapy – Authors' reply
In the largest series of islet transplant recipients treated with a common protocol of islet preparation and post-transplantation care (the Edmonton protocol), only 16 of 36 patients were still insulin-independent at 1 year; 10 had complete graft loss. Consistently, comparative studies have found that only 31% of islet recipients versus 96% of whol...
The Lancet - Jul 4, 2008 10:48 AM

β-cell transplantation for diabetes therapy
...treatment of diabetes.
The Lancet - Jul 4, 2008 10:48 AM

β-cell transplantation for diabetes therapy
Piero Ruggenenti and colleagues (March 15, p 883) highlight their failure to establish a clinical islet transplantation programme. Results of islet transplantation are similar to those of the early days of organ transplantation, where initial success rarely met with long-term function. The Edmonton protocol achieved reproducible insulin independenc...
The Lancet - Jul 4, 2008 10:48 AM

CORRECTIONS: Metformin versus Insulin for the Treatment of Gestational Diabetes
...of Gestational Diabetes . In the abstract (page 2003), under Results, the parenthetical information should read "(relative risk, 0.99; 95% confidence interval, 0.80 to ...
New England Journal of Medicine - Jul 2, 2008 10:20 PM

Book: Handle with care
...Primary Care Diabetes Society conference. I wanted to know more about the disease that, according to the 2002 report by Sir Derek Wanless, threatens to bankrupt the UK's National Health Service (NHS) over the next decade. It already costs the NHS more than £1 billion a year, most of which can be put down to failures in prevention and management ...
The Lancet - Jun 27, 2008 10:17 AM

Chronic kidney disease in Asia
...such as diabetes, hypertension, and metabolic syndrome, have become common and, as a result, chronic kidney disease has become a prevalent comorbidity in the past 10 years.
The Lancet - Jun 27, 2008 10:17 AM

Type 2 diabetes: pathogenesis and treatment
...type 2 diabetes mellitus, several important developments have taken place. Further evidence that the disease has a strong hereditary component led to a vigorous search to identify candidate genes (). This approach uncovered two prevalent polymorphisms (in addition to PPARy and KCNJ11). HNF1B (MODY5) bears a polymorphism associated with type 2 di...
The Lancet - Jun 27, 2008 10:17 AM

[RESEARCH] Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2
...type 2 diabetes, renal disease, atrial fibrillation, and rheumatoid arthritis. Results The validation statistics indicated that QRISK2 had improved discrimination and calibration compared with the modified Framingham score. The QRISK2 algorithm explained 43% of the variation in women and 38% in men compared with 39% and 35%, respectively, by the...
BMJ current issue - Jun 27, 2008 12:09 AM