This week's Diabetes Bulletin...

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Friday, 12 September 2008

Diabetes Technology and Therapeutics, Vol 10, Part 5

We do not have full text access to this journal. Recent articles are available via inter-library loan. Please contact the library if you would like to order an article.

Article Title:
Long - Acting Insulin Analogs Versus Human Insulins
Author(s):
Garg , Satish K . ; Naik , Ramachandra G .
ISSUE:
2008 ; VOL 10 ; PART 5 (2008/10/01)
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Diabetes Technology and Therapeutics
Page:
331-332
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Article Title:
Beyond the Era of NPH Insulin - Long - Acting Insulin Analogs : Chemistry , Comparative Pharmacology , and Clinical Application
Author(s):
Owens , D . R . ; Bolli , G . B .
ISSUE:
2008 ; VOL 10 ; PART 5 (2008/10/01)
Access:
Diabetes Technology and Therapeutics
Page:
333-349
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Article Title:
Validation of the SoloSTAR Insulin Pen
Author(s):
Schwartz , Sherwyn ; Vlajnic , Aleksandra
ISSUE:
2008 ; VOL 10 ; PART 5 (2008/10/01)
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Diabetes Technology and Therapeutics
Page:
351-357
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Article Title:
Dose Accuracy Comparison Between SoloSTAR and FlexPen at Three Different Dose Levels
Author(s):
Penfornis , Alfred ; Horvat , Kristian
ISSUE:
2008 ; VOL 10 ; PART 5 (2008/10/01)
Access:
Diabetes Technology and Therapeutics
Page:
359-362
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Article Title:
Comparison of Gliclazide with Insulin as Initial Treatment Modality in Newly Diagnosed Type 2 Diabetes
Author(s):
Chandra , Satish T . ; Priya , Gagan ; Khurana , Madan L . ; Jyotsna , Viveka P . ; Sreenivas , V . ; Dwivedi , Sadanand ; Ammini , Ariachery C .
ISSUE:
2008 ; VOL 10 ; PART 5 (2008/10/01)
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Diabetes Technology and Therapeutics
Page:
363-368
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Article Title:
Improved Glycemic Control in Intensively Treated Adult Subjects with Type 1 Diabetes Using Insulin Guidance Software
Author(s):
Garg , Satish K . ; Bookout , Tevin R . ; McFann , Kim K . ; Kelly , William C . ; Beatson , Christie ; Ellis , Samuel L . ; Gutin , Raymond S . ; Gottlieb , Peter A
ISSUE:
2008 ; VOL 10 ; PART 5 (2008/10/01)
Access:
Diabetes Technology and Therapeutics
Page:
369-375
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Article Title:
Sensor - Augmented Insulin Pump Therapy : Results of the First Randomized Treat - to - Target Study
Author(s):
Hirsch , Irl B . ; Abelseth , Jill ; Bode , Bruce W . ; Fischer , Jerome S . ; Kaufman , Francine R . ; Mastrototaro , John ; Parkin , Christopher G . ; Wolpert , Howard A . ; Buckingham , Bruce A .
ISSUE:
2008 ; VOL 10 ; PART 5 (2008/10/01)
Access:
Diabetes Technology and Therapeutics
Page:
377-383
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Article Title:
The Accuracy and Efficacy of Real - Time Continuous Glucose Monitoring Sensor in Patients with Type 1 Diabetes
Author(s):
Mastrototaro , John ; Shin , John ; Marcus , Alan ; Sulur , Giri ; for the STAR 1 Clinical Trial Investigators
ISSUE:
2008 ; VOL 10 ; PART 5 (2008/10/01)
Access:
Diabetes Technology and Therapeutics
Page:
385-390
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Article Title:
Pramlintide Reduces the Risks Associated with Glucose Variability in Type 1 Diabetes
Author(s):
Kovatchev , Boris P ; Crean , John ; McCall , Anthony
ISSUE:
2008 ; VOL 10 ; PART 5 (2008/10/01)
Access:
Diabetes Technology and Therapeutics
Page:
391-396
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Article Title:
Prevalence of Albuminuria and Cardiovascular Risk Profile in a Referred Cohort of Patients with Type 2 Diabetes : An Asian Perspective
Author(s):
Pan , C . Y . ; Ho , L . T . ; Soegondo , S . ; Prodjosudjadi , W . ; Suwanwalaikorn , S . ; Lim , S . C . ; Chan , T . M . ; Chow , K . W . Steven ; Thoenes , M . ; Choi , D . S . ; on behalf of the DEMAND Study Investigators
ISSUE:
2008 ; VOL 10 ; PART 5 (2008/10/01)
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Diabetes Technology and Therapeutics
Page:
397-403
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Article Title:
Effects of Chromium Picolinate on Food Intake and Satiety
Author(s):
Anton , Stephen D . ; Morrison , Christopher D . ; Cefalu , William T . ; Martin , Corby K . ; Coulon , Sandra ; Geiselman , Paula ; Han , Hongmei ; White , Christy L . ; Williamson , Donald A .
ISSUE:
2008 ; VOL 10 ; PART 5 (2008/10/01)
Access:
Diabetes Technology and Therapeutics
Page:
405-412
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Article Title:
Role of Emerging New Technologies
Author(s):
Garg , Satish K
ISSUE:
2008 ; VOL 10 ; PART 5 (2008/10/01)
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Diabetes Technology and Therapeutics
Page:
413-414
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Article Title:
Comments on Evaluation of Five Glucose Meters by Thomas et al .
Author(s):
Simmons , David A
ISSUE:
2008 ; VOL 10 ; PART 5 (2008/10/01)
Access:
Diabetes Technology and Therapeutics
Page:
415
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Article Title:
Response to Simmons
Author(s):
Kane , Michael P . ; Hamilton , Robert A .
ISSUE:
2008 ; VOL 10 ; PART 5 (2008/10/01)
Access:
Diabetes Technology and Therapeutics
Page:
417
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Article Title:
Clinical Application of Emerging Sensor Technologies in Diabetes Management : Consensus Guidelines for Continuous Glucose Monitoring ( CGM )
Author(s):
Hirsch , Irl B . ; Armstrong , Dana ; Bergenstal , Richard M . ; Buckingham , Bruce ; Childs , Belinda P . ; Clarke , William L . ; Peters , Anne ; Wolpert , Howard
ISSUE:
2008 ; VOL 10 ; PART 4 (2008/08/01)
Access:
Diabetes Technology and Therapeutics
Page:
232-246
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Article Title:
Initiating Insulin Therapy in Type 2 Diabetes : Benefits of Insulin Analogs and Insulin Pens
Author(s):
Brunton , Stephen
ISSUE:
2008 ; VOL 10 ; PART 4 (2008/08/01)
Access:
Diabetes Technology and Therapeutics
Page:
247-256
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Article Title:
Progress Toward an In Vivo Surface - Enhanced Raman Spectroscopy Glucose Sensor
Author(s):
Lyandres , Olga ; Yuen , Jonathan M . ; Shah , Nilam C . ; VanDuyne , Richard P . ; Walsh , Joseph T . ; Glucksberg , Matthew R .
ISSUE:
2008 ; VOL 10 ; PART 4 (2008/08/01)
Access:
Diabetes Technology and Therapeutics
Page:
257-265
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Article Title:
The Accuracy of the Guardian® ; RT Continuous Glucose Monitor in Children with Type 1 Diabetes
Author(s):
The Diabetes Research in Children Network ( DirecNet ) Study Group
ISSUE:
2008 ; VOL 10 ; PART 4 (2008/08/01)
Access:
Diabetes Technology and Therapeutics
Page:
266-272
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Article Title:
Reduced Weight Gain with Insulin Detemir Compared to NPH Insulin Is Not Explained by a Reduction in Hypoglycemia
Author(s):
Davies , Melanie J . ; Derezinski , Tadeusz ; Pedersen , Claus Bang ; Clauson , Per
ISSUE:
2008 ; VOL 10 ; PART 4 (2008/08/01)
Access:
Diabetes Technology and Therapeutics
Page:
273-277
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Article Title:
Influence of Diabetes on the Validity Glaucoma Screening by Frequency Doubling Perimetry : A Hospital - Based Study in Oman
Author(s):
Khandekar , Rajiv ; Zutshi , Rajiv ; Ali , Mohammed ; Raisi , Abdulatif Al ; Dass , Henry
ISSUE:
2008 ; VOL 10 ; PART 4 (2008/08/01)
Access:
Diabetes Technology and Therapeutics
Page:
278-282
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Article Title:
Modeling Glucose and Water Dynamics in Human Skin
Author(s):
Groenendaal , W . ; Schmidt , K . A . ; von Basum , G . ; van Riel , N . A . W . ; Hilbers , P . A . J .
ISSUE:
2008 ; VOL 10 ; PART 4 (2008/08/01)
Access:
Diabetes Technology and Therapeutics
Page:
283-293
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Article Title:
The Effects of Magnetic Field on the Biomechanics Parameters of Soleus and Extensor Digitorum Longus Muscles in Rats with Streptozotocin - Induced Diabetes
Author(s):
Pelit , A . ; è ; Ozaykan , B . ; Tuli , A . ; Demirkazik , A . ; Emre , M . ; Gè ; unay , I .
ISSUE:
2008 ; VOL 10 ; PART 4 (2008/08/01)
Access:
Diabetes Technology and Therapeutics
Page:
294-298
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Article Title:
Patient Acceptance and Issues of Education of Two Durable Insulin Pen Devices
Author(s):
Asakura , Toshinari ; Seino , Hiroaki ; Jensen , Klaus H .
ISSUE:
2008 ; VOL 10 ; PART 4 (2008/08/01)
Access:
Diabetes Technology and Therapeutics
Page:
299-304
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Article Title:
Immunogenicity of Human and Bovine Insulin in Type 1 Diabetes Mellitus Patients
Author(s):
Himanshu , M . ; Bhat , Chetan B . ; Ramchandran , Sarita ; Bhat , K . Geetha ; Kumar , Prasanna K . M .
ISSUE:
2008 ; VOL 10 ; PART 4 (2008/08/01)
Access:
Diabetes Technology and Therapeutics
Page:
305-309
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Article Title:
JDRF Randomized Clinical Trial to Assess the Efficacy of Real - Time Continuous Glucose Monitoring in the Management of Type 1 Diabetes : Research Design and Methods
Author(s):
JDRF CGM Study Group
ISSUE:
2008 ; VOL 10 ; PART 4 (2008/08/01)
Access:
Diabetes Technology and Therapeutics
Page:
310-321
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Article Title:
Dosing Accuracy with a Novel Pen Device ( SoloSTAR® ; ) as Performed by Patients with Diabetes in a Clinical Setting
Author(s):
Hermanns , Norbert ; Kulzer , Bernhard ; Haak , Thomas
ISSUE:
2008 ; VOL 10 ; PART 4 (2008/08/01)
Access:
Diabetes Technology and Therapeutics
Page:
322-327
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Article Title:
Torcetrapib as Potential Treatment of Low High - Density Lipoprotein Cholesterol : No Longer a Pipe Dream ?
Author(s):
Ahmed , Mohamed H
ISSUE:
2008 ; VOL 10 ; PART 4 (2008/08/01)
Access:
Diabetes Technology and Therapeutics
Page:
328-329
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Diabetes Vol 57, Part 9

We have full text access to this journal. Click here to view the articles. You will need an NHS Athens password from ECNHST.

Article Title:
Bringing Light to the Dark Side of Insulin : A Journey Across the Blood - Brain Barrier
Author(s):
Robert S . Sherwin
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2259 - 2268
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Article Title:
Revascularization of Transplanted Islets : Can It Be Improved ?
Author(s):
Marcela Brissova
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2269 - 2271
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Article Title:
Pyruvate Dehydrogenase Kinase 4 : Regulation by Thiazolidinediones and Implication in Glyceroneogenesis in Adipose Tissue
Author(s):
Thomas Cadoudal
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2272 - 2279
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Article Title:
Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion
Author(s):
Sara Edfalk
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2280 - 2287
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Article Title:
Pioglitazone Decreases Fasting and Postprandial Endogenous Glucose Production in Proportion to Decrease in Hepatic Triglyceride Content
Author(s):
Balasubramanian Ravikumar
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2288 - 2295
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Article Title:
Carcinoembryonic Antigen - Related Cell Adhesion Molecule 1 : A Link Between Insulin and Lipid Metabolism
Author(s):
Anthony M . DeAngelis
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2296 - 2303
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Article Title:
Intracerebroventricular Administration of Neuropeptide Y Induces Hepatic Insulin Resistance via Sympathetic Innervation
Author(s):
Anita M . van den Hoek
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2304 - 2310
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Article Title:
Deletion of Cd39 / Entpd1 Results in Hepatic Insulin Resistance
Author(s):
Keiichi Enjyoji
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2311 - 2320
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Article Title:
Metabolically Favorable Remodeling of Human Adipose Tissue by Human Adenovirus Type 36
Author(s):
Pamela M . Rogers
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2321 - 2331
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Article Title:
Cholinergic Regulation of Ghrelin and Peptide YY Release May Be Impaired in Obesity
Author(s):
Christina Maier
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2332 - 2340
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Article Title:
Rapamycin Monotherapy in Patients With Type 1 Diabetes Modifies CD4 + CD25 + FOXP3 + Regulatory T - Cells
Author(s):
Paolo Monti
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2341 - 2347
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Article Title:
Impact of Diabetes Susceptibility Loci on Progression From Pre - Diabetes to Diabetes in At - Risk Individuals of the Diabetes Prevention Trial - Type 1 ( DPT - 1 )
Author(s):
Vincent Butty
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2348 - 2359
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Article Title:
Plasmacytoid Precursor Dendritic Cells From NOD Mice Exhibit Impaired Function : Are They a Component of Diabetes Pathogenesis ?
Author(s):
Yiming Huang
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2360 - 2370
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Article Title:
Exendin - 4 Stimulation of Cyclin A2 in ß - Cell Proliferation
Author(s):
Woo - Jin Song
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2371 - 2381
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Article Title:
Palmitate Impairs and Eicosapentaenoate Restores Insulin Secretion Through Regulation of SREBP - 1c in Pancreatic Islets
Author(s):
Toyonori Kato
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2382 - 2392
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Article Title:
Formation of Composite Endothelial Cell - Mesenchymal Stem Cell Islets : A Novel Approach to Promote Islet Revascularization
Author(s):
Ulrika Johansson
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2393 - 2401
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Article Title:
Switching - On Survival and Repair Response Programs in Islet Transplants by Bone Marrow - Derived Vasculogenic Cells
Author(s):
Robyn Miller
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2402 - 2412
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Article Title:
HES - 1 Is Involved in Adaptation of Adult Human ß - Cells to Proliferation In Vitro
Author(s):
Yael Bar
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2413 - 2420
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Article Title:
Reduction of Ptf1a Gene Dosage Causes Pancreatic Hypoplasia and Diabetes in Mice
Author(s):
Akihisa Fukuda
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2421 - 2431
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Article Title:
The Fatty Acid Receptor GPR40 Plays a Role in Insulin Secretion In Vivo After High - Fat Feeding
Author(s):
Melkam Kebede
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2432 - 2437
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Article Title:
Increase in Endoplasmic Reticulum Stress - Related Proteins and Genes in Adipose Tissue of Obese , Insulin - Resistant Individuals
Author(s):
Guenther Boden
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2438 - 2444
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Article Title:
Evidence for Interindividual Heterogeneity in the Glucose Gradient Across the Human Red Blood Cell Membrane and Its Relationship to Hemoglobin Glycation
Author(s):
Paramjit K . Khera
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2445 - 2452
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Article Title:
Effects of a Selective Serotonin Reuptake Inhibitor , Fluoxetine , on Counterregulatory Responses to Hypoglycemia in Healthy Individuals
Author(s):
Vanessa J . Briscoe
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2453 - 2460
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Article Title:
Receptor for Advanced Glycation End Products ( RAGE ) Deficiency Attenuates the Development of Atherosclerosis in Diabetes
Author(s):
Aino Soro - Paavonen
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2461 - 2469
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Article Title:
Differential Roles of Cardiomyocyte and Macrophage Peroxisome Proliferator - Activated Receptor &ggr ; in Cardiac Fibrosis
Author(s):
Evren Caglayan
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2470 - 2479
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Article Title:
Metabolic Phenotypes , Vascular Complications , and Premature Deaths in a Population of 4 , 197 Patients With Type 1 Diabetes
Author(s):
Ville - Petteri Mä ; kinen
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2480 - 2487
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Article Title:
Carbon Monoxide and Nitric Oxide Mediate Cytoskeletal Reorganization in Microvascular Cells via Vasodilator - Stimulated Phosphoprotein Phosphorylation : Evidence for Blunted Responsiveness in Diabetes
Author(s):
Sergio Li Calzi
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2488 - 2494
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Article Title:
Pericyte Migration : A Novel Mechanism of Pericyte Loss in Experimental Diabetic Retinopathy
Author(s):
Frederick Pfister
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2495 - 2502
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Article Title:
Extension of Type 2 Diabetes Genome - Wide Association Scan Results in the Diabetes Prevention Program
Author(s):
Allan F . Moore
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2503 - 2510
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Article Title:
Prevalence of Melanocortin - 4 Receptor Deficiency in Europeans and Their Age - Dependent Penetrance in Multigenerational Pedigrees
Author(s):
Fanny Stutzmann
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2511 - 2518
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Article Title:
High - Density Single Nucleotide Polymorphism Genome - Wide Linkage Scan for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes : Discordant Sibpair Approach
Author(s):
John J . Rogus
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2519 - 2526
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Article Title:
Evaluating the Role of LPIN1 Variation in Insulin Resistance , Body Weight , and Human Lipodystrophy in U . K . Populations
Author(s):
Katherine A . Fawcett
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2527 - 2533
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Article Title:
Association Testing of Novel Type 2 Diabetes Risk Alleles in the JAZF1 , CDC123 / CAMK1D , TSPAN8 , THADA , ADAMTS9 , and NOTCH2 Loci With Insulin Release , Insulin Sensitivity , and Obesity in a Population - Based Sample of 4 , 516 Glucose - Tolerant Middle - Aged Danes
Author(s):
Niels Grarup
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2534 - 2540
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Article Title:
Is the Presence of Retinopathy of Practical Value in Defining Cases of Diabetic Nephropathy in Genetic Association Studies ? : The Experience With the ACE Insertion / Deletion Polymorphism in 53 Studies Comprising 17 , 791 Subjects
Author(s):
Daniel P . K . Ng
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2541 - 2546
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Article Title:
Exclusion of Polymorphisms in Carnosinase Genes ( CNDP1 and CNDP2 ) as a Cause of Diabetic Nephropathy in Type 1 Diabetes : Results of Large Case - Control and Follow - Up Studies
Author(s):
Krzysztof Wanic
ISSUE:
2008 ; VOL 57 ; PART 9 (2008-September)
Access:
From Free Medical Journals . com (/1998 - /Embargo: 3 months)
Page:
2547 - 2551
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Friday, 29 August 2008

BMJ Learning Modules

The following diabetes modules are available using your NHS Athens password, to see more diabetes related modules go to http://www.bmjlearning.com/:

Diabetes mellitus type 2: an update on management
Many advances have been made in the treatment of type 2 diabetes. Would you like an update on postprandial glucose regulators, DPP-4 inhibitors, insulin glargine and detemir? This recently updated module will tell you all about these important drugs. Click on the link to complete it today.

Hypoglycaemia: diagnosis and management
Hypoglycaemia is one of the most unpleasant and feared acute complications of diabetes. The symptoms and signs can be overlooked in the early stages. Prompt effective treatment should be readily available. Complete this module to improve the diagnosis and management of people who experience episodes of hypoglycaemia

Recent Big 4 diabetes articles

[Department of Error] Department of Error
...type 2 diabetes on oral hypoglycaemic agents (APOLLO): an open randomised controlled trial. Lancet 2008; 371: 1073–84—In this Article (March 29), the fifth line from the bottom of the panel (p 1075) should have read: “≤5·5 mmol/L: no further titration”. The second sentence of the footnote to table 2 (p 1079) should have read: “Fasting blood gluc...
The Lancet - 10:40 (1 hour ago)


[Correspondence] Intensive insulin therapy in patients with type 2 diabetes – Authors' reply
...latent autoimmune diabetes in adults in our population. Although there is no formal consensus regarding diagnostic criteria, the disorder is generally defined as GAD antibody positivity in adult diabetic patients who do not initially (for at least 6 months) require insulin. Usually patients with latent autoimmune diabetes have a low body-mass in...
The Lancet - 10:40 (1 hour ago)


[Correspondence] Intensive insulin therapy in patients with type 2 diabetes
...type 2 diabetes (May 24, p 1573) is an exciting prospect.
The Lancet - 10:40 (1 hour ago)


[Correspondence] Intensive insulin therapy in patients with type 2 diabetes
Jianping Weng and colleagues are to be commended for building a concept that could change clinical practice. However, their conclusions need some clarification.
The Lancet - 10:40 (1 hour ago)


CORRESPONDENCE: Widespread Amyloid Deposition in Transplanted Human Pancreatic Islets
...type 1 diabetes mellitus, diagnosed at 16 years of age, in ...
New England Journal of Medicine - 27 Aug 2008 (2 days ago)



CARING FOR THE CRITICALLY ILL PATIENT: Benefits and Risks of Tight Glucose Control in Critically Ill Adults: A Meta-analysis
...The American Diabetes Association and Surviving Sepsis Campaign recommend tight glucose control in critically ill patients based largely on 1 trial that shows decreased mortality in a surgical intensive care unit. Because similar studies report conflicting results and tight glucose control can cause dangerous hypoglycemia, the data underlying th...
JAMA current issue - 26 Aug 2008 (3 days ago)


[RESEARCH] Role of blood pressure in development of early retinopathy in adolescents with type 1 diabetes: prospective cohort study
...type 1 diabetes. Design Prospective cohort study. Setting Diabetes Complications Assessment Service at the Children’s Hospital at Westmead, Sydney, Australia. Participants 1869 patients with type 1 diabetes (54% female) screened for retinopathy with baseline median age 13.4 (interquartile range 12.0-15.2) years, duration 4.9 (3.1-7.0) years, and...
BMJ current issue - 26 Aug 2008 (3 days ago)


[EDITORIALS] Complications of type 1 diabetes in adolescents
BMJ current issue - 26 Aug 2008 (3 days ago)


[NEWS] Diabetes care needs to focus more on ethnic inequalities, say experts
BMJ current issue - 22 Aug 2008 16:46

[PRACTICE] Should we prescribe diuretics for patients with prediabetes and hypertension?
BMJ current issue - 21 Aug 2008 14:44


LETTERS: Insulin Therapy and Lipid Overload in Type 2 Diabetes--Reply
JAMA current issue - 19 Aug 2008 21:44

LETTERS: Insulin Therapy and Lipid Overload in Type 2 Diabetes
JAMA current issue - 19 Aug 2008 21:44

LETTERS: Pioglitazone vs Glimepiride in the PERISCOPE Trial
JAMA current issue - 19 Aug 2008 21:44


EDITORIAL: Environmental Arsenic Exposure and Diabetes
JAMA current issue - 19 Aug 2008 21:44

LETTERS: Pioglitazone vs Glimepiride in the PERISCOPE Trial--Reply
JAMA current issue - 19 Aug 2008 21:44



LETTERS: Pioglitazone vs Glimepiride in the PERISCOPE Trial
JAMA current issue - 19 Aug 2008 21:44


LETTERS: Insulin Therapy and Lipid Overload in Type 2 Diabetes
JAMA current issue - 19 Aug 2008 21:44


PRELIMINARY COMMUNICATION: Arsenic Exposure and Prevalence of Type 2 Diabetes in US Adults
...related to diabetes development, but the effect of exposure to low to moderate levels of inorganic arsenic on diabetes risk is unknown. In contrast, arsenobetaine, an organic arsenic compound derived from seafood intake, is considered nontoxic. Objective To investigate the association of arsenic exposure, as measured in urine, with the prevalen...
JAMA current issue - 19 Aug 2008 21:44

[Seminar] Acute myocardial infarction
...epidemic of diabetes and obesity in the developed world and the transition from infectious diseases to cardiovascular disease in the developing world will place an increasing demand on health-care infrastructures required to deliver time-dependent and resource-intensive care. This Seminar discusses the underlying pathophysiology, evolving perspe...
The Lancet - 15 Aug 2008 11:00

[Articles] Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial
...or with diabetes with end-organ damage.
The Lancet - 15 Aug 2008 11:00

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 25-2008 -- A 43-Year-Old Man with Fatigue and Lesions in the Pituitary and Cerebellum
...Diabetes insipidus, hypogonadism, and hypothyroidism had developed beginning 9 years earlier, and lesions had been detected in the region of the pituitary stalk and in the cerebellum. He was treated with glucocorticoids for suspected neurosarcoidosis, but fatigue, ataxia, and neurologic symptoms worsened. Computed tomography of the chest and abd...
New England Journal of Medicine - 13 Aug 2008 22:25

[CORRECTIONS] Evidence shows higher long term risks from gestational diabetes
BMJ current issue - 6 Aug 2008 17:36

Basal insulin glargine vs prandial insulin lispro in type 2 diabetes
Reinhard Bretzel and colleagues (March 29, p 1073) compared once-daily insulin glargine with thrice-daily prandial insulin lispro as add-on therapy to continued oral hypoglycaemic agents. Although glycosylated haemoglobin did not differ between regimens, the overall incidence of hypoglycaemic events was four times higher with insulin lispro than wi...
The Lancet - 1 Aug 2008 11:15

Basal insulin glargine vs prandial insulin lispro in type 2 diabetes – Authors' reply
Sabine Arnolds and Klaus Rave state that the higher hypoglycaemic rate in the lispro group than in the glargine group was potentiated by the presence of glimepiride. However, the relative frequencies of hypoglycaemic events by hour of day showed a similar distribution profile, with peaks at 2 pm for lispro and 3 pm for glargine. A further explanati...
The Lancet - 1 Aug 2008 11:15

Department of Health (DH) Publication

Five years on: delivering the diabetes national service framework http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_087123

NICE guidance updates

The following guidance matching your health area preferences has been published or updated:

Diabetes (type 2) - newer agents
Diabetes - insulin pump therapy
Diabetes - type 2 (update)
Type 1 diabetes
Diabetes - type 2 (update)

Diabetes Care Vol 31; Part 8; August 2008

We have full text access to these articles. Click here to access the journal. You will need an NHS Athens password to access the full text of articles.


Evaluation of a System for Automatic Detection of Diabetic Retinopathy From Color Fundus Photographs in a Large Population of Patients With Diabetes : Response to Abrà ; moff et al .
Author(s):John A . Olson
Page:
e63 - e63

Evaluation of a System for Automatic Detection of Diabetic Retinopathy From Color Fundus Photographs in a Large Population of Patients With Diabetes : Response to Olson et al .
Author(s):Michael D . Abrà ; moff
Page:
e64 - e64

Translating the A1C Assay Into Estimated Average Glucose Values
Author(s):David M . Nathan
Page:
1473 - 1478

Colesevelam HCl Improves Glycemic Control and Reduces LDL Cholesterol in Patients With Inadequately Controlled Type 2 Diabetes on Sulfonylurea - Based Therapy
Author(s):Vivian A . Fonseca
Page:
1479 - 1484

Influence of and Optimal Insulin Therapy for a Low - Glycemic Index Meal in Children With Type 1 Diabetes Receiving Intensive Insulin Therapy
Author(s):Rochelle L . Ryan
Page:
1485 - 1490

Optimizing Postprandial Glycemia in Pediatric Patients With Type 1 Diabetes Using Insulin Pump Therapy : Impact of glycemic index and prandial bolus type
Author(s):Michele A . O'Connell
Page:
1491 - 1495

Clinical Application of 1 , 5 - Anhydroglucitol Measurements in Patients with Hepatocyte Nuclear Factor - 1&agr ; Maturity - Onset Diabetes of the Young
Author(s):Jan Skupien
Page:
1496 - 1501

Hemodynamic Effects of Fenofibrate and Coenzyme Q10 in Type 2 Diabetic Subjects With Left Ventricular Diastolic Dysfunction
Author(s):Gerard T . Chew
Page:
1502 - 1509

Cost - Effectiveness of Intensified Versus Conventional Multifactorial Intervention in Type 2 Diabetes : Results and projections from the Steno - 2 study
Author(s):Peter Gæ ; de
Page:
1510 - 1515

Diabetes Complications in Youth : Qualitative analysis of parents` perspectives of family learning and knowledge
Author(s):
Lisa M . Buckloh
Page:
1516 - 1520

Monitoring and Discussing Health - Related Quality of Life in Adolescents With Type 1 Diabetes Improve Psychosocial Well - Being : A randomized controlled trial
Author(s):Maartje de Wit
Page:
1521 - 1526

Blood Glucose Awareness Training Delivered Over the Internet
Author(s):Daniel Cox
Page:
1527 - 1528

Evaluation of a Systems Navigator Model for Transition From Pediatric to Adult Care for Young Adults With Type 1 Diabetes
Author(s):Norma Van Walleghem
Page:
1529 - 1530

Impaired Chronotropic Response to Exercise Stress Testing in Patients With Diabetes Predicts Future Cardiovascular Events
Author(s):P . Michael Ho
Page:
1531 - 1533

Association of 1 , 5 - Anhydroglucitol and 2 - h Postprandial Blood Glucose in Type 2 Diabetic Patients
Author(s):
Christoph Stettler
Page:
1534 - 1535

Risks of Nontraumatic Lower - Extremity Amputations in Patients with Type 1 Diabetes : A population - based cohort study in Sweden
Author(s):
Junmei Miao Jonasson
Page:
1536 - 1540

Diabetes , Glycemic Control , and Risk of Hospitalization With Pneumonia : A population - based case - control study
Author(s):
Jette B . Kornum
Page:
1541 - 1545

The Rising Incidence of Type 1 Diabetes Is Accounted for by Cases With Lower - Risk Human Leukocyte Antigen Genotypes
Author(s):
Spiros Fourlanos
Page:
1546 - 1549

Insulin Sensitivity Measured With Euglycemic Clamp Is Independently Associated With Glomerular Filtration Rate in a Community - Based Cohort
Author(s):
Elisabet Nerpin
Page:
1550 - 1555

Economic Benefits of Intensive Insulin Therapy in Critically Ill Patients : The Targeted Insulin Therapy to Improve Hospital Outcomes ( TRIUMPH ) Project
Author(s):
Archana R . Sadhu
Page:
1556 - 1561

Health Care Use and Costs Associated With Use of a Health Club Membership Benefit in Older Adults with Diabetes
Author(s):
Huong Q . Nguyen
Page:
1562 - 1567

Dietary Patterns and A1C in Japanese Men and Women
Author(s):
Akiko Nanri
Page:
1568 - 1573

Increased Risk of Diabetes and Polychlorinated Biphenyls and Dioxins : A 24 - year follow - up study of the Yucheng cohort
Author(s):
Shu - Li Wang
Page:
1574 - 1579

Sexual Dysfunction in Jordanian Diabetic Women
Author(s):
Ruba M . Abu Ali
Page:
1580 - 1581

Lifetime Risk of Cardiovascular Disease Among Individuals With and Without Diabetes Stratified by Obesity Status in the Framingham Heart Study
Author(s):
Caroline S . Fox
Page:
1582 - 1584

Association Between p . Leu54Met Polymorphism at the Paraoxonase - 1 Gene and Plantar Fascia Thickness in Young Subjects With Type 1 Diabetes
Author(s):
Patricia H . Gallego
Page:
1585 - 1589

Hyperglycemia Is Associated With Enhanced Thrombin Formation , Platelet Activation , and Fibrin Clot Resistance to Lysis in Patients With Acute Coronary Syndrome
Author(s):
Anetta Undas
Page:
1590 - 1595

Diminished Alveolar Microvascular Reserves in Type 2 Diabetes Reflect Systemic Microangiopathy
Author(s):
William W . Chance
Page:
1596 - 1601

GAD65 Autoantibody Responses in Japanese Latent Autoimmune Diabetes in Adult Patients
Author(s):
Taro Maruyama
Page:
1602 - 1607

Differences in the Contribution of the CTLA4 Gene to Susceptibility to Fulminant and Type 1A Diabetes in Japanese Patients
Author(s):
Eiji Kawasaki
Page:
1608 - 1610

Epidermal Innervation in Type 1 Diabetic Patients : A 2 . 5 - year prospective study after simultaneous pancreas / kidney transplantation
Author(s):
Petr Boucek
Page:
1611 - 1612

Short - Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function
Author(s):
Sebastiaan Hammer
Page:
1613 - 1614

Serum Bilirubin and Ferritin Levels Link Heme Oxygenase - 1 Gene Promoter Polymorphism and Susceptibility to Coronary Artery Disease in Diabetic Patients
Author(s):
Ying - Hwa Chen
Page:
1615 - 1620

Association of Acculturation Levels and Prevalence of Diabetes in the Multi - Ethnic Study of Atherosclerosis ( MESA )
Author(s):
Namratha R . Kandula
Page:
1621 - 1628

Preventing Left Ventricular Hypertrophy by ACE Inhibition in Hypertensive Patients With Type 2 Diabetes : A prespecified analysis of the Bergamo Nephrologic Diabetes Complications Trial ( BENEDICT )
Author(s):
Piero Ruggenenti
Page:
1629 - 1634

Dysglycemia and a History of Reproductive Risk Factors
Author(s):
Sarah D . McDonald
Page:
1635 - 1638

Risk of Glucose Intolerance and Diabetes in Hemipancreatectomized Donors Selected for Normal Preoperative Glucose Metabolism
Author(s):
Anjali F . Kumar
Page:
1639 - 1643

Increased Daily Walking Improves Lipid Oxidation Without Changes in Mitochondrial Function in Type 2 Diabetes
Author(s):
Michael I . Trenell
Page:
1644 - 1649

One - Hour Plasma Glucose Concentration and the Metabolic Syndrome Identify Subjects at High Risk for Future Type 2 Diabetes
Author(s):
Muhammad A . Abdul - Ghani
Page:
1650 - 1655

Dose - Dependent Effect of Rosuvastatin on VLDL - Apolipoprotein C - III Kinetics in the Metabolic Syndrome
Author(s):
Esther M . M . Ooi
Page:
1656 - 1661

Sex - Specific Association of the Putative Fructose Transporter SLC2A9 Variants With Uric Acid Levels Is Modified by BMI
Author(s):
Anita Br and stä ; tter
Page:
1662 - 1667

Increased Risk of Cardiovascular Disease in Young Women Following Gestational Diabetes Mellitus
Author(s):
Baiju R . Shah
Page:
1668 - 1669

Validation of Prediction of Diabetes by the Archimedes Model and Comparison With Other Predicting Models
Author(s):
Michael Stern
Page:
1670 - 1671

Is the Combination of Sulfonylureas and Metformin Associated With an Increased Risk of Cardiovascular Disease or All - Cause Mortality ? : A meta - analysis of observational studies
Author(s):
Ajay D . Rao
Page:
1672 - 1678

Comprehensive Foot Examination and Risk Assessment : A report of the Task Force of the Foot Care Interest Group of the American Diabetes Association , with endorsement by the American Association of Clinical Endocrinologists
Author(s):
Andrew J . M . Boulton
Page:
1679 - 1685

The Impact of Prevention on Reducing the Burden of Cardiovascular Disease
Author(s):
Richard Kahn
Page:
1686 - 1696

Approaches to Treatment of Type 2 Diabetes
Author(s):
Zachary T . Bloomgarden
Page:
1697 - 1703

Translating the A1C Assay
Author(s):
Richard Kahn
Page:
1704 - 1707

Reducing Cardiovascular Disease : Opportunities and consequences
Author(s):
Peter J . Neumann
Page:
1708 - 1709

Friday, 1 August 2008

Big 4 Diabetes articles

Access
BMJ - current paper copy in library, electronic access 3 months delay - NHS Athens
Lancet - electronic access 2 months delay - NHS Athens
JAMA - current electronic access - NHS Athens
NEJM - current paper copy in library, partial electronic access to recent articles - no password
full text electronic access - 3 months delay - NHS Athens

HEALTH AGENCIES UPDATE: Pesticides-Diabetes Link
JAMA current issue - 22 Jul 2008 21:34

EDITORIAL: Diabetes Mellitus--A Call for Papers
JAMA current issue - 22 Jul 2008 21:34

LETTERS: Oral Hypoglycemic Use and the SANDS Trial
JAMA current issue - 22 Jul 2008 21:34

COMMENTARY: Heart Failure With Preserved Ejection Fraction: Treat Now by Treating Comorbidities
JAMA current issue - 22 Jul 2008 21:34

LETTERS: Oral Hypoglycemic Use and the SANDS Trial--Reply
JAMA current issue - 22 Jul 2008 21:34

HEALTH AGENCIES UPDATE: Drugs and Cancer Risk
JAMA current issue - 22 Jul 2008 21:34

Statins for children?
...hypertension or diabetes, and those whose family history is unknown should also be screened.
The Lancet - 18 Jul 2008 10:44

BOOK REVIEW: Controversies in Treating Diabetes: Clinical and Research Aspects
Shortly before his election as president, John F. Kennedy wrote, "Let us welcome controversial books and controversial authors." To this statement we might add "and books on controversial medical topics," ...
New England Journal of Medicine - 16 Jul 2008 22:27

ORIGINAL CONTRIBUTION: Fetuin-A and Incident Diabetes Mellitus in Older Persons
...type 2 diabetes mellitus is unknown. Objective To determine whether fetuin-A levels are associated with incident diabetes in older persons. Design, Setting, and Participants Observational study among 3075 well-functioning persons aged 70 to 79 years. In this case-cohort study, we retrospectively measured fetuin-A levels in baseline serum among...
JAMA current issue - 8 Jul 2008 21:39

β-cell transplantation for diabetes therapy
In their Comment, Piero Ruggenenti and colleagues outline why they have decided not to continue islet-cell transplantation. We wish to clarify several points for readers.
The Lancet - 4 Jul 2008 10:48

β-cell transplantation for diabetes therapy – Authors' reply
In the largest series of islet transplant recipients treated with a common protocol of islet preparation and post-transplantation care (the Edmonton protocol), only 16 of 36 patients were still insulin-independent at 1 year; 10 had complete graft loss. Consistently, comparative studies have found that only 31% of islet recipients versus 96% of whol...
The Lancet - 4 Jul 2008 10:

β-cell transplantation for diabetes therapy
...treatment of diabetes.
The Lancet - 4 Jul 2008 10:48

β-cell transplantation for diabetes therapy
Piero Ruggenenti and colleagues (March 15, p 883) highlight their failure to establish a clinical islet transplantation programme. Results of islet transplantation are similar to those of the early days of organ transplantation, where initial success rarely met with long-term function. The Edmonton protocol achieved reproducible insulin independenc...
The Lancet - 4 Jul 2008 10:48

CORRECTIONS: Metformin versus Insulin for the Treatment of Gestational Diabetes
...of Gestational Diabetes . In the abstract (page 2003), under Results, the parenthetical information should read "(relative risk, 0.99; 95% confidence interval, 0.80 to ...
New England Journal of Medicine - 2 Jul 2008 22:20

Diabetes Vol 57, Part 7, 2008

We have full text access to this journal. Click here and login using NHS Athens

Protein kinase C function in muscle , liver , and beta - cells and its therapeutic implications for type 2 diabetes
Author(s):Schmitz - Peiffer , C . ; Biden , T . J .
ISSUE:2008 ; VOL 57 ; PART 7 (2008-July)
Page:1774-1783

Plasma C5 glucose - to - ^ 2H ~ 2O ratio does not provide an accurate assessment of gluconeogenesis during hyperinsulinemic - euglycemic clamps in either nondiabetic or diabetic humans
Author(s):Basu , R . ; Chandramouli , V . ; Dicke , B . ; Landau , B . R . ; Rizza , R . A
ISSUE:2008 ; VOL 57 ; PART 7 (2008-July)
Page:1800-1804

Blockade of alpha 4 integrin signaling ameliorates the metabolic consequences of high - fat diet - induced obesity
Author(s):Feral , C . C . ; Neels , J . G . ; Kummer , C . ; Slepak , M . ; Olefsky , J . M . ; Ginsberg , M . H .
ISSUE:2008 ; VOL 57 ; PART 7 (2008-July)
Page:1842-1851

Diabetes Care Vol 31, Part 7, 2008

We have full text access to this journal using NHS Athens. Click here to access.

Tumor necrosis factor - alpha antagonism improves vasodilation during hyperinsulinemia in metabolic syndrome
Author(s):Tesauro , M . ; Schinzari , F . ; Rovella , V . ; Melina , D . ; Mores , N . ; Barini , A . ; Mettimano , M . ; Lauro , D . ; Iantorno , M . ; Quon , M . J
ISSUE:2008 ; VOL 31 ; PART 7 (2008-July)
Page:1439-1441

Meta - Analysis Rosiglitazone and risk of cancer : a meta - analysis of randomized clinical trials
Author(s):Monami , M . ; Lamanna , C . ; Marchionni , N . ; Mannucci , E .
ISSUE:2008 ; VOL 31 ; PART 7 (2008-July)
Page:1455-1460

Perspectives on the News Approaches to treatment of pre - diabetes and obesity and promising new approaches to type 2 diabetes
Author(s):Bloomgarden , Z . T
ISSUE:2008 ; VOL 31 ; PART 7 (2008-July)
Page:1461-1466

Editorial Death to carbohydrate counting ?
Author(s):Davis , N . J . ; Wylie - Rosett , J .
ISSUE:2008 ; VOL 31 ; PART 7 (2008-July)
Page:1467-1468

NICE updates

The following guidance matching your health area preferences has been published or updated:

Diabetes - insulin pump therapy
Diabetes - insulin pump therapy
Diabetes in pregnancy

National Prescribing Centre's 'Week in Review' 4/7/08

NPCi Blog http://www.npci.org.uk/blog/
· MeReC Rapid Review: Is aliskiren plus losartan renoprotective in patients with type 2 diabetes and nephropathy? http://www.npci.org.uk/blog/?p=160

InfoPOEMs: http://www.essentialevidenceplus.com/
· Metformin effective for gestational diabetes http://www.essentialevidenceplus.com/infopoems/dailyInfoPOEM.cfm?view=121866

National electronic Library for Medicines (NeLM): http://www.nelm.nhs.uk
· FDA panel says diabetes drugs need cardiovascular risk studies http://www.nelm.nhs.uk/Record%20Viewing/vR.aspx?id=594929

Friday, 18 July 2008

Latest Diabetes articles in the Big 4

BOOK REVIEW: Controversies in Treating Diabetes: Clinical and Research Aspects
Shortly before his election as president, John F. Kennedy wrote, "Let us welcome controversial books and controversial authors." To this statement we might add "and books on controversial medical topics," ...
New England Journal of Medicine - Jul 16, 2008 (2 days ago)

ORIGINAL CONTRIBUTION: Fetuin-A and Incident Diabetes Mellitus in Older Persons
...type 2 diabetes mellitus is unknown. Objective To determine whether fetuin-A levels are associated with incident diabetes in older persons. Design, Setting, and Participants Observational study among 3075 well-functioning persons aged 70 to 79 years. In this case-cohort study, we retrospectively measured fetuin-A levels in baseline serum among...
JAMA current issue - Jul 8, 2008 9:39 PM

β-cell transplantation for diabetes therapy
In their Comment, Piero Ruggenenti and colleagues outline why they have decided not to continue islet-cell transplantation. We wish to clarify several points for readers.
The Lancet - Jul 4, 2008 10:48 AM

β-cell transplantation for diabetes therapy – Authors' reply
In the largest series of islet transplant recipients treated with a common protocol of islet preparation and post-transplantation care (the Edmonton protocol), only 16 of 36 patients were still insulin-independent at 1 year; 10 had complete graft loss. Consistently, comparative studies have found that only 31% of islet recipients versus 96% of whol...
The Lancet - Jul 4, 2008 10:48 AM

β-cell transplantation for diabetes therapy
...treatment of diabetes.
The Lancet - Jul 4, 2008 10:48 AM

β-cell transplantation for diabetes therapy
Piero Ruggenenti and colleagues (March 15, p 883) highlight their failure to establish a clinical islet transplantation programme. Results of islet transplantation are similar to those of the early days of organ transplantation, where initial success rarely met with long-term function. The Edmonton protocol achieved reproducible insulin independenc...
The Lancet - Jul 4, 2008 10:48 AM

CORRECTIONS: Metformin versus Insulin for the Treatment of Gestational Diabetes
...of Gestational Diabetes . In the abstract (page 2003), under Results, the parenthetical information should read "(relative risk, 0.99; 95% confidence interval, 0.80 to ...
New England Journal of Medicine - Jul 2, 2008 10:20 PM

Book: Handle with care
...Primary Care Diabetes Society conference. I wanted to know more about the disease that, according to the 2002 report by Sir Derek Wanless, threatens to bankrupt the UK's National Health Service (NHS) over the next decade. It already costs the NHS more than £1 billion a year, most of which can be put down to failures in prevention and management ...
The Lancet - Jun 27, 2008 10:17 AM

Chronic kidney disease in Asia
...such as diabetes, hypertension, and metabolic syndrome, have become common and, as a result, chronic kidney disease has become a prevalent comorbidity in the past 10 years.
The Lancet - Jun 27, 2008 10:17 AM

Type 2 diabetes: pathogenesis and treatment
...type 2 diabetes mellitus, several important developments have taken place. Further evidence that the disease has a strong hereditary component led to a vigorous search to identify candidate genes (). This approach uncovered two prevalent polymorphisms (in addition to PPARy and KCNJ11). HNF1B (MODY5) bears a polymorphism associated with type 2 di...
The Lancet - Jun 27, 2008 10:17 AM

[RESEARCH] Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2
...type 2 diabetes, renal disease, atrial fibrillation, and rheumatoid arthritis. Results The validation statistics indicated that QRISK2 had improved discrimination and calibration compared with the modified Framingham score. The QRISK2 algorithm explained 43% of the variation in women and 38% in men compared with 39% and 35%, respectively, by the...
BMJ current issue - Jun 27, 2008 12:09 AM

Latest Diabetes News from the National Library for Health

MeReC Monthly (June 2008): Self-monitoring in type 2 diabetes
via NeLM news - Diabetes on 7/7/08
The latest edition of MeReC Monthly reviews the use of routine self-monitoring of blood glucose (SMBG), noting that two recent studies (ESMON and DiGEM economic analysis) have reinforced the view that it is unlikely to be beneficial in patients with type 2 diabetes who are not treated with insulin and may worsen quality of life and waste NHS resources. Therefore it should be reserved for patients treated with insulin and for non-insulin treated patients in specific circumstances, as recommended in recent NICE guidance on type 2 diabetes (see link).

SMC accepts restricted use of Eucreas tablets (vildagliptin 50mg + metformin 850mg or 1000mg) for type 2 diabetes
via NeLM news - Diabetes 7/7/08
Following a review of an abbreviated submission (used for new formulations at same or lesser cost, and new tablet strength or size), the Scottish Medicines Consortium (SMC) has accepted for restricted use within NHS Scotland, Eucreas® tablets (vildagliptin 50mg/metformin 850mg and vildagliptin 50mg /metformin 1000mg). ...

Meta-analysis: Pregabalin for painful diabetic neuropathy
via NeLM news - Diabetes on 6/7/08
Pregabalin is effective for treatment of painful diabetic neuropathy across its usual dose range, according to a meta-analysis sponsored by the drug's manufacturer and part-authored by company employees. A number of controlled trials have been carried out with pregabalin in patients with painful diabetic neuropathy, however they have used different dose regimens: this analysis was carried out to evaluate the drug's efficacy and safety in this condition at all effective doses....

DTB: exenatide (Byetta), sitagliptin (Januvia), and vildagliptin (Galvus) for type 2 diabetes
via NeLM news - Diabetes on 6/7/08
The July edition of the Drug and Therapeutics Bulletin (DTB) features a review of three new treatments for type 2 diabetes: exenatide (Byetta®), sitagliptin (Januvia®), and vildagliptin (Galvus®). It discusses the incretins and glucose metabolism, examines the trial data and its limitations, and looks at national guidelines....

FDA panel says diabetes drugs need cardiovascular risk studies
via NeLM news - Diabetes on 2/7/08
PharmaTimes reports that the US Food and Drug Administration’s (FDA) Endocrinologic and Metabolic Drugs Advisory Committee has advised US regulators they should insist that studies on new diabetes treatments include much more data on the potential heart risks of the treatments....

FDA to consider necessity of cardiovascular studies for diabetes drugs
via NeLM news - Diabetes on 30/6/08
According to a report in the Wall Street Journal, the US FDA is summoning a panel of experts to consider whether pharmaceutical companies should be required to study the cardiovascular effects of diabetes drugs prior to approval. The report points out that cardiovascular endpoints are relatively rare and therefore large, long-term studies would be required to demonstrate any statistically significant effects; this could slow the development of new drugs and would increase costs.

FDA approves PrandiMet (repaglinide and metformin) for type 2 diabetes
via NeLM news - Diabetes on 24/6/08
According to BioSpace, the FDA has approved PrandiMet™ (repaglinide and metformin) tablets as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus who are already treated with a meglitinide [the drug class that repaglinide belongs to] and metformin or who have inadequate glycaemic control on a meglitinide alone or metformin alone. Please see the link above for details.

Benefits of intensive glucose control in older type 2 diabetics limited by co-morbidity
via NeLM news - Diabetes on 30/6/08
A decision analysis study suggests that for older patients with type 2 diabetes, intensive blood glucose control becomes less useful with increasing co-morbidity and functional impairment; chronological age alone, however, was not useful for predicting benefit. Intensive control of blood glucose has been shown to be beneficial in type 1 diabetes, and may also improve outcomes in type 2 diabetes....

25 June 2008 - My life
via NLH Diabetes Specialist Library Whats New by Diane Clay on 25/6/08
How to manage your diabetes as a young adult, moving away from home, taking control of your life


NPC iblog: Putting blood glucose control in type 2 diabetes into perspective
via NeLM news - Diabetes on 16/6/08
The National Prescribing Centre have published an iblog discussing a “Perspective” article published in the New England Journal of Medicine, that discusses the implications of ACCORD and ADVANCE studies, alongside some other major clinical studies that evaluated the benefits of reducing risk factors, such as blood lipids, blood pressure and blood glucose levels on preventing cardiovascular (CV) disease....

Antipsychotic agents and diabetes: meta-analysis plus study data on aripiprazole
via NeLM news - Diabetes by nelm@gstt.nhs.uk on 15/6/08
Second-generation antipsychotic drugs are associated with a small increase in risk of diabetes compared to first-generation drugs, according to a meta-analysis, although retrospective analysis of data from a clinical trial suggests that an increased risk with aripiprazole may be less likely....

15 June 2008 - Interesting new diabetes papers April 2008
via NLH Diabetes Specialist Library Whats New on 15/6/08
The latest edition of Dr Roger Gadsbys bulletin is now available

11 June 2008 - Diabetic retinopathy screening
via NLH Diabetes Specialist Library Whats New on 11/6/08
Statement published by the Department of Health on 3 April 2008

11 June 2008 - Joint Position Statement - Integrated Care in the Reforming NHS
via NLH Diabetes Specialist Library Whats New on 11/6/08
A joint publication by Diabetes UK, the Association of British Clinical Diabetologists (ABCD), the Primary Care Diabetes Society (PCDS), Community Diabetes Consultants (CDC) and the RCN Diabetes Nursing Forum issued in December 2007

Diabetes, Vol 57, Part 6 

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A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K^+channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults
Author(s):Tarasov , A . I . ; Nicolson , T . J . ; Riveline , J . - P . ; Taneja , T . K . ; Baldwin , S . A . ; Baldwin , J . M . ; Charpentier , G . ; Gautier , J . - F . ; Froguel , P . ; Vaxillaire , M .
ISSUE:2008 ; VOL 57 ; PART 6
Page:
1595-1604


Critical roles for macrophages in islet angiogenesis and maintenance during pancreatic degeneration

Author(s):Tessem , J . S . ; Jensen , J . N . ; Pelli , H . ; Dai , X . - M . ; Zong , X . - H . ; Stanley , E . R . ; Jensen , J . ; Degregori , J .
ISSUE:2008 ; VOL 57 ; PART 6
Page:1605-1617


Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion
Author(s):Braun , M . ; Ramracheya , R . ; Bengtsson , M . ; Zhang , Q . ; Karanauskaite , J . ; Partridge , C . ; Johnson , P . R . ; Rorsman , P .
ISSUE:2008 ; VOL 57 ; PART 6
Page:1618-1628


Elevated epidermal growth factor receptor phosphorylation induces resistance artery dysfunction in diabetic db/db mice
Author(s):Belmadani , S . ; Palen , D . I . ; Gonzalez - Villalobos , R . A . ; Boulares , H . A . ; Matrougui , K .
ISSUE:2008 ; VOL 57 ; PART 6
Page:1629-1637


beta-Cell dysfunction in subjects with impaired glucose tolerance and early type 2 diabetes: comparison of surrogate markers with first-phase insulin secretion from an intravenous glucose tolerance test
Author(s):Festa , A . ; Williams , K . ; Hanley , A . J . G . ; Haffner , S . M .
ISSUE:2008 ; VOL 57 ; PART 6
Page:1638-1644

Retinal and cerebral microvascular signs and diabetes: the Age, Gene/Environment Susceptibility-Reykjavik Study
Author(s):Qiu , C . ; Cotch , M . F . ; Sigurdsson , S . ; Garcia , M . ; Klein , R . ; Jonasson , F . ; Klein , B . E . K . ; Eiriksdottir , G . ; Harris , T . B . ; Van Buchem , M . A .
ISSUE:2008 ; VOL 57 ; PART 6
Page:1645-1650

Suppressors of cytokine-signaling proteins induce insulin resistance in the retina and promote survival of retinal cells
Author(s):Liu , X . ; Mameza , M . G . ; Lee , Y . S . ; Eseonu , C . I . ; Yu , C . - R . ; Derwent , J . J . K . ; Egwuagu , C . E .
ISSUE:2008 ; VOL 57 ; PART 6
Page:1651-1658

Persistent hyperinsulinemic hypoglycemia and maturity-onset diabetes of the young due to heterozygous HNF4A mutations
Author(s):Kapoor , R . R . ; Locke , J . ; Colclough , K . ; Wales , J . ; Conn , J . J . ; Hattersley , A . T . ; Ellard , S . ; Hussain , K .
ISSUE:2008 ; VOL 57 ; PART 6
Page:1659-1663

Distal degenerative sensory neuropathy in a long-term type 2 diabetes rat model
Author(s):Brussee , V . ; Guo , G . ; Dong , Y . ; Cheng , C . ; Martinez , J . A . ; Smith , D . ; Glazner , G . W . ; Fernyhough , P . ; Zochodne , D . W .
ISSUE:2008 ; VOL 57 ; PART 6
Page:1664-1673

Decreased lipoprotein clearance is responsible for increased cholesterol in LDL receptor knockout mice with streptozotocin-induced diabetes
Author(s):Goldberg , L . J . ; Hu , Y . ; Noh , H . - L . ; Wei , J . ; Huggins , L . A . ; Rackmill , M . G . ; Hamai , H . ; Reid , B . N . ; Blaner , W . S . ; Huang , L . - S .
ISSUE:2008 ; VOL 57 ; PART 6
Page:1674-1682

RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease
Author(s):Peng , F . ; Wu , D ; Gao , B . ; Ingram , A . J . ; Zhang , B . ; Chorneyko , K . ; McKenzie , R . ; Krepinsky , J . C .
ISSUE:2008 ; VOL 57 ; PART 6
Page:1683-1692


Abnormal muscle spindle innervation and large-fiber neuropathy in diabetic mice
Author(s):Muller , K . A . ; Ryals , J . M . ; Feldman , E . L . ; Wright , D . E .
ISSUE:2008 ; VOL 57 ; PART 6
Page:1693-1701

Haptoglobin genotype: a determinant of cardiovascular complication risk in type 1 diabetes
Author(s):Costacou , T . ; Ferrell , R . E . ; Orchard , T . J .
ISSUE:2008 ; VOL 57 ; PART 6
Page:1702-1706


Having one kidney does not accelerate the rate of development of diabetic nephropathy lesions in type 1 diabetic patients
Author(s):Chang , S . ; Caramori , M . L . ; Moriya , R . ; Mauer , M .
ISSUE:2008 ; VOL 57 ; PART 6
Page:1707-1711


Urinary Smad1 is a novel marker to predict later onset of mesangial matrix expansion in diabetic nephropathy
Author(s):Mima , A . ; Arai , H . ; Matsubara , T . ; Abe , H . ; Nagai , K . ; Tamura , Y . ; Torikoshi , K . ; Araki , M . ; Kanamori , H . ; Takahashi , T
ISSUE:2008 ; VOL 57 ; PART 6
Page:1712-1722

Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats
Author(s):Han , S . ; Hagan , D . L . ; Taylor , J . R . ; Xin , L . ; Meng , W . ; Biller , S . A . ; Wetterau , J . R . ; Washburn , W . N . ; Whaley , J . M .
ISSUE:2008 ; VOL 57 ; PART 6
Page:1723-1729

PTPN22 Trp^ 6^ 2^ 0 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes
Author(s):Smyth , D . J . ; Cooper , J . D . ; Howson , J . M . M . ; Walker , N . M . ; Plagnol , V ; Stevens , H . ; Clayton , D . G . ; Todd , J . A .
ISSUE:2008 ; VOL 57 ; PART 6
Page:1730-1737


Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes
Author(s):Holmkvist , J . ; Almgren , P . ; Lyssenko , V . ; Lindgren , C . M . ; Eriksson , K . - F ; Isomaa , B . ; Tuomi , T . ; Nilsson , P . ; Groop , L .
ISSUE:2008 ; VOL 57 ; PART 6
Page:1738-1744


The diabetic phenotype in HNF4A mutation carriers is moderated by the expression of HNF4A isoforms from the P1 promoter during fetal development
Author(s):Harries , L . W . ; Locke , J . M . ; Shields , B . ; Hanley , N . A . ; Hanley , K . P . ; Steele , A . ; Njolstad , P . R . ; Ellard , S . ; Hattersley , A . T
ISSUE:2008 ; VOL 57 ; PART 6
Page:
1745-1752


Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes

Author(s):Field , S . F . ; Nejentsev , S . ; Walker , N . M . ; Howson , J . M . M . ; Godfrey , L M . ; Jolley , J . D . ; Hardy , M . P . A . ; Todd , J . A
ISSUE:2008 ; VOL 57 ; PART 6
Page:1753-1756